ROLE OF PLK1/NUMB/NOTCH IN EPITHELIAL-MESENCHYMAL TRANSITION IN HUMAN MELANOMA

Abstract Polo-like kinase 1 (PLK1), a serine/threonine kinase, is overexpressed in melanoma and its expression has been associated with poor disease prognosis.PLK1 has been shown to interact with NUMB, a NOTCH antagonist.However, the exact role of PLK1, NUMB, and NOTCH signaling in epithelial-mesenchymal transition (EMT) in melanoma progression is

During the onset of an inflammatory response signaling pathways are activated for "translating" extracellular signals into intracellular responses converging General Wound Care - Compression Bandage to the activation of nuclear factor (NF)-kB, a central transcription factor in driving the inflammatory response.An inadequate control of its transcrip